Clues to preventing cancers

For many years Integrated Medicine has known that many factors play into creating cancerous conditions in the body. Some of

Vitamin D3
Vitamin D3

these include, but are not limited to eating foods that create an acidic condition in the body like meats, milk products, processed foods and sugar. Anything that changes the pH to acidic from the normal alkaline can create a breeding grounds for cell/DNA changes including long lasting deep seated repressed emotions.

Now Cedric Garland, DrPH, professor of family and preventive medicine at the UC San Diego School of Medicine, and his research team explain that with enough vitamin D and calcium present, cells adhere to one another in tissue and act as normal, mature epithelial cells. If there is a deficiency of vitamin D, cells can lose their sticking ability as well as their identity as differentiated cells. When this happens, they may revert to a dangerous stem cell-like state and become cancerous.

In 2008, Dr. Garland and his colleagues found an association between a lack of sunlight exposure, low vitamin D and breast cancer. In earlier work, they showed linkages between increased levels of vitamin D3 or markers of vitamin D and a lower risk for breast, colon, ovarian and kidney cancers, too

Resources

Excerpts courtesy of Naturalnews.com/026447_Vitamin_D_cancer_NaturalNews

Image courtesy of  Wikimedia.org/wikipedia/commons/Cholecalciferol

Silver hair and health

Watch what you affirm.

Some say things like you are a pain in the neck when they are mad at some one. Then often times end up with a stiff neck or some discomfort in their neck .grey-hair585_204681a

Science now has found another link between the graying of one’s hair and stress. Now “genotoxic stress,” or stress from the toxic effects of chemicals or energy in our environment can damage DNA, like ultraviolet light. The researchers found that this cellular stress diminishes the supply of melanocyte stem cells (MSC) – cells in hair follicles that are responsible for making the pigment-producing cells that give hair its color.not necessarily age related and the stresses in one’s life.

melanin storage in melanocyte
melanin storage in melanocyte

Integrated medicine has known about this connection for year and routinely treat and help poeple destress. Applied kinesiology and homeopathy hves perfected the art of relieving the stress from physical, memory, emotional, and situational stres.
Melanocyte stem cells are so-called “adult stem cells.” They are not mature hair cells and they can continuously divide and supply our hair with the pigment producing cells it needs to have color. When a melanocyte stem cell matures into a pigment producing cell, or melanocyte, it is called differentiation.

For more information on ways to decreases stress in your life.

Resources

Excerpts courtesy of news.yahoo.com/s/livescience/rootsofgrayhairfoundincellularstress
Excerpts courtesy of livescience.com/health/080115-stress

Image 1. courtesy of  cdn-write.demandstudios.com/

Image 2. courtesy of    scf-online.com/issue22/images22/IllustrationMelanin22

"Restoring hearing and vision in animals with stem cells"

Stem cells can develop into many different cell types in the body during early life and growth. In many tissues they serve as a sort of internal repair system, dividing essentially without limit to replenish other cells as long as the person or animal is still alive. When a stem cell divides, each new cell has the potential either to remain a stem cell or become another type of cell with a more specialized function, such as a muscle cell, a red blood cell, or a brain cell. Without these cells human tissues could not survive and we would die when the first cells wore out.

many types of stem cells
many types of stem cells

Bone marrow stem cells from humans  has restored the lost hearing and vision in embryonic guinea pigs.This may be the key to unlock the first step toward helping people. Another group of researchers  grew functioning eyes in tadpoles using frog cells.

Stem cell research hold extraordinary promise for treating a wide range of deadly and disabling diseases that plague millions.
How did they grow hearing cells?

By cultivating stem cells into neuron-like cells in petri dishes and then harvesting and transplanted them into the inner ears of the guinea pigs within three months later, the animals appeared to have some hearing, The goal was to regrow the tiny hair cells that are essential for mammals to hear.
What damages these hair cells?

“When sensitive hair cells in the inner ear of humans and other mammals are killed — by loud noise, autoimmune attack, toxic drugs, or aging — the damage is permanent. Humans cannot naturally replace them, other animals like birds and reptiles can automatically regenerate hearing cells.

Michael Zuber and colleagues at the SUNY Upstate Medical University in Syracuse, New York, grew functioning eyes in blinded frog embryos using stem cells.

In frog usually stem cells only form skin when grown in vitro. Zuber’s team of researchers discovered thatby  adding seven different stimulating genetic “factors” eye formation genes were turned on..

When they transplanted the transformed cells into frog embryos, the resulting tadpoles could see out of those eyes, Zuber told the meeting. Genetic tests showed that the stem cells had transformed, a process called differentiation, into many different cell types. all cell types needed for vision were formed again.

Resources

Excerpts courtesy of stemcells.nih.gov/info/basics

Excerpts courtesy of Rueters.com Stem cells restore hearing, vision in animals
– Maggie Fox,  Health And Science Editor  Reuters– Wed Nov 19, 2008.

Image courtesy of csa.com/discoveryguides/stemcell/pluri

Odor to make humans disappear- mosquitoes confusants

19-1The image at the right is an
electron micrograph of the head of a female Anopheles gambiae mosquito, showing the parts of olfactory appendages (antennae, maxillary palps and proboscis)

Dr. Leslie Vosshall and two colleagues at Rockefeller University published a series of experiments that seemed to settle the 50-year-old question of how the insect repellent DEET kept mosquitoes at bay (Science, 319:1838-42, 2008).

Vosshal explained their findings “It doesn’t smell bad to insects. It masks or inhibits their ability to smell you.”
The Bill & Melinda Gates Foundation funded the research to understand how and why DEET works. This is critical to creating the next generation of chemicals, which may head off insect-borne diseases such as malaria and dengue fever.
Related Articles
Laurence Zwiebel of Vanderbilt University (also a Gates’ grantee) and  Ulrich Bernier of the US Department of Agriculture are not sure the findings just didn’t make sense, given everything they knew about this system

In Vosshall experiment,  the response of the mosquito’s olfactory neurons to two separate, attractive odors in human breath. Then, she combined each odorant with DEET in a single odor cartridge and noticed a smaller neural response. Vosshall believes DEET was blocking the mosquito’s olfactory co-receptor.
Another teams experiment another interpretation

Using gas chromatography, Leal confirmed his suspicions this year. When he repeated Vosshall’s experiment using separate odor cartridges that blended DEET and each attractive odor only at their tips, the mosquito’s neural response was no longer diminished. Then, Leal identified a DEET-sensitive odor receptor neuron and showed that mosquitoes avoid passing through a “curtain” of DEET vapors.
Leal’s paper surprised Vosshall, but is unconvinced by Leal’s results, and has been trying to reproduce the effect in her own lab. “Competition in science is good,” she says, “It can be difficult when it’s a small field, and this is a very small field.”

Genomic studies in 2005 have since shown that this co-receptor is found in insects ranging from mosquitoes to moths,  making humans invisible to insects. Using tissue cultures, she uses targeted drug discovery to screen 91,520 compounds from a chemical library, short-listing about 150 that she believes have the potential to be insect “confusants.”

Even Vosshall’s skeptics admit the confusant strategy is fundamentally sound. Zwiebel says his unpublished molecular work confirms the existence of confusants, but when it comes to DEET, he and Vosshall aren’t willing to budge. “We have agreed to disagree on the DEET story,” he says.

Resources

Smells funny? – Brendan Borrell  The Scientist.com Volume 23 | Issue 1 | Page 19.

http://www.the-scientist.com/2009/01/1/19/1/

Mosquitoes smell and avoid the insect repellent DEET – Leal and Zainulabeuddin Syed,  PNAS 105:13598-603, 2008 September 2008.


Image courtesy
of LJ Zwiebel, colorization by Dominic Doyle / Vanderbilt University

How do ipRGCs effect our sleep and health?

siod_eye_cells_04The 24  hour biological clock that creates a balance for  health and harmony in the body runs on light. Changes in levels of in light effect the photosensitive retinal ganglion cells (ipRGCs).  located behind the rods and cones of the retina in the eye. When darkness falls and we go to bed. As the eyes close, the change in light intensity (or lack of light) is registered on these ipRGC cells and a message is sent to the hypothalamicCircadian rhythm Suprachiasmatic Nucleus (SCN) and the olivarypretectal nucleus (OPN) located in the frontal part of the brain (behind the area between your eyebrows)” it is time to sleep”. Then the SCN and OPN begin the night time hormone production. This cascade of hormones is part of the   body’s  circadian rhythms.

There is only 1,000 to 2,000cells gauge the overall light intensity branch-like  ipRGCs eye cells in mammals are responsible for telling the body clock whether it was day or night and when to turn melatonin on for a restful sleep.

Next Importance of melatonin to our health and wellness.

Image courtesy of www.livescience.com

WHO sets melamine limits

WHO sets first limits for safe melamine levels in food-safe this is an industrial chemical that has a cumulative effect on living kidney tissues.

GET RID OF IT1melamine-chem

Demand to know how many products and how much melamine and cyanuatic acid its cousin is tainting our milk and food supply, Then do not buy from companies that use these poisons.

Melamine has been routinely mixed into Chinese milk and dairy products to give them the impression of having higher protein content and a richer flavor, Cyanuratic acid has been used to clean equipment.

The World Health Organization (WHO) on December 5, 2008 issued safety limits for melamine levels in food as international concern mounted over a widening tainted food scandal in China.

It is the first time WHO experts have issued safety limits for the use of the industrial chemical and they stressed that melamine should not be used in food at all.

The so-called Tolerable Daily Intake (TDI) has been fixed at 0.2 mg per kilogramme of body weight. This means that a person who weighs 50kg can tolerate up to 10mg of melamine per day, said the WHO.

For how long is it tolerable for our neonats and our infants?

The UN agency stressed however that the industrial chemical “should not be in food” even though traces are sometimes unavoidable?

“The TDI is meant to help national authorities set safe limits in food for withdrawal purposes should melamine be detected as a result of intentional adulteration,” added the WHO.

The scandal has led many countries around the world, including the 27-nation European Union, to ban Chinese milk imports and Chinese foods containing soya and Chinese-made baking powder will also have to be tested after high levels of melamine were found.

How come they can do something about it while the US does little to nothing to protect our children? We have no idea if melamine is effecting any other age group.

China said Monday that 294,000 children had been made ill by consuming dairy products containing melamine, with 154 still in serious condition.

China said six deaths since September may have been caused by tainted dairy products. The “confirmed ” death toll so far is three infants.

Beware of tainting of prooducts any food or condiment that has been in contact with melamine including chicken eggs, soya products, candy any Chines food products are suspect now.

The full impact of melamine in international food products and agriculture stock and their feed has just begun to be felt.

BUY CERTIFIED ORGANIC PRODUCTS.
WHO sets first limits for safe melamine levels in food – Staff Writers
Geneva (AFP) Dec 5, 2008 Seed Daily.com
http://www.seeddaily.com/reports/WHO_sets_first_limits_for_safe_melamine_levels_in_food_999.htmlhttp://www.seeddaily.com/reports/WHO_sets_first_limits_for_safe_melamine_levels_in_food_999.htmlEED DAILY

image courtesy

http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=7955

"Nanoparticles the next major health hazard"

The potential health threats of Nanoparticles :

“When materials are brought down to the nanoscale dimension, their properties for some performance characteristics dramatically change,” said Cagin. ” We have demonstrated that when you go to a particular length scale between 20 and 23 nanometers you actually improve the energy-harvesting capacity by 100 percent.

The gold and silver nanoparticles are beginning to come under close scrutity.

Nanoparticles could threaten human organs such as the liver, heart, kidneys and lungs and brain. Nanoparticles are found in the air, products, soil and through medicine and medical procedures. the problem is that they are so tiny a single particle is one billionth of a meter (3.9 feet) and they accumulate where they lodge. Lodging in the ear after cell phone use; on the body after wearing clothes made withem or wearing them as a medical device or applying them on the skin in the form of retinol A or sunscreen. There have been no long term studies to understand the effects on biological systems including the human body. Now biologicval systems mean no studies on what happen as they enter cells whether it is plant or animal -what does it do to the DNA and other cell organelles and is the effects carried into the chromosomes for the next generation to deal with.

Gold nanoparticles are everywhere. They are used in cancer treatments, automobile sensors, cell phones, blood sugar monitors and hydrogen gas production. However, until recently, scientists couldn’t create the nanoparticles without producing synthetic chemicals that had negative impacts on the environment.gallery-nanoparticle-toxicity-large

“The smaller a particle, the further it can travel through tissue, along airways or in blood vessels,” Dr. Adnan Nasir, a clinical assistant professor of dermatology at the University of North Carolina at Chapel Hill, told The New York Times. “Especially if the nanoparticles are indestructible and accumulate and are not metabolized, if you accumulate them in the organs, the organs could fail,” he said.

Minuscule nanoparticles added to consumer products increasingly may be swarming through the body and threatening organs like the liver, U.S. scientists fear. “The smaller a particle, the further it can travel through tissue, along airways or in blood vessels,” Dr. Adnan Nasir, a clinical assistant professor of dermatology at the University of North Carolina at Chapel Hill, told The New York Times. “Especially if the nanoparticles are indestructible and accumulate and are not metabolized, if you accumulate them in the organs, the organs could fail,” he said.

Even when made of inert elements, nanomaterials take on unique properties, research suggests. Animal studies indicate nanoparticles can penetrate cells and tissues, move through the body and brain and cause biochemical damage. They have also been linked to testicular cancer and cardiovascular system damage and may pose an environmental hazard, studies suggest. Even a separate study by the U.S. Commerce Department’s National Institute of Standards and Technology found stoves and toaster ovens emit ultrafine particles of 2 to 30 nanometers.

Their use in lotions and creams particularly in mineral sunscreens has drawn the most critical attention. Consumer products with nanoparticles or based on nanotechnology like clothing, surface treatment, cosmetics and transports. Through these products the most direct contact to consumers occur. The potential health problems related to the use of the products need to be studied immediately and assessed.

The U.S. Environmental Agency is seeking public review and comment on a petition asking the agency to classify nanoscale silver as a pesticide.
The petition, filed by the International Center for Technology Assessment and others, also calls on the EPA to require formal pesticide registration of all products containing nanoscale silver, analyze the potential human health and environmental risks of the tiny germ-killing particles, and take regulatory action against existing products that contain the material.

“Nanosilver is an unknown threat not only to the environment but also to human health,” center staff attorney George Kimbrell said. “The public has no idea that consumer products contain potentially dangerous nanoparticles because no labeling is currently required.”

The petition, filed by the International Center for Technology Assessment and others, also calls on the EPA to require formal pesticide registration of all products containing nanoscale silver, analyze the potential human health and environmental risks of the tiny germ-killing particles, and take regulatory action against existing products that contain the material.

The center said manufacturers are infusing products with nanoscale silver for its enhanced anti-microbial abilities. There are more than 260 nanosilver products currently on the market, including household appliances and cleaners, clothing, cutlery, children’s toys and personal care products.

“Nanosilver is an unknown threat not only to the environment but also to human health,” center staff attorney George Kimbrell said. “The public has no idea that consumer products contain potentially dangerous nanoparticles because no labeling is currently required.”

“Nanosilver is an unknown threat not only to the environment but also to human health,” center staff attorney George Kimbrell said. “The public has no idea that consumer products contain potentially dangerous nanoparticles because no labeling is currently required.”

Environmental danger

Kimbrell said silver is toxic to fish, aquatic organisms and microorganisms. A 2008 study showed that washing nanosilver socks released substantial amounts of the nanosilver into laundry discharge water, which will ultimately reach natural waterways, the center said.
“Nanosilver is an unknown threat not only to the environment but also to human health,” center staff attorney George Kimbrell said. “The public has no idea that consumer products contain potentially dangerous nanoparticles because no labeling is currently required.”

Kimbrell said silver is toxic to fish, aquatic organisms and microorganisms. A 2008 study showed that washing nanosilver socks released substantial amounts of the nanosilver into laundry discharge water, which will ultimately reach natural waterways, the center said.

The U.S. Environmental Agency is seeking public review and comment on a petition asking the agency to classify nanoscale silver as a pesticide.
The petition, filed by the International Center for Technology Assessment and others, also calls on the EPA to require formal pesticide registration of all products containing nanoscale silver, analyze the potential human health and environmental risks of the tiny germ-killing particles, and take regulatory action against existing products that contain the material.

The center said manufacturers are infusing products with nanoscale silver for its enhanced anti-microbial abilities. There are more than 260 nanosilver products currently on the market, including household appliances and cleaners, clothing, cutlery, children’s toys and personal care products.

“Nanosilver is an unknown threat not only to the environment but also to human health,” center staff attorney George Kimbrell said. “The public has no idea that consumer products contain potentially dangerous nanoparticles because no labeling is currently required.” Nanoparticles are used in sun screens to block ultraviolet radiation, in emulsions to contain vitamins in face creams, and in other moisturisers to kill off bacteria. But of 67 firms approached only eight submitted information on the use of nanotechnology in their products. until all the necessary safety tests are carried out, the simple fact is we just don’t know enough.

Individuals must take care of their own health and family safety. The government has not yet required manufacturers of nanomaterials products to have an independent assessment and long term research to determine the safety of all products.

Industry response

In May researchers at the Institute of Occupational Medicine, Edinburgh, asked the government to restrict use of carbon nanotubes – in car panels, tennis rackets and bike frames – claiming they posed a cancer risk similar to that of asbestos.

Kimbrell said silver is toxic to fish, aquatic organisms and microorganisms. A 2008 study showed that washing nanosilver socks released substantial amounts of the nanosilver into laundry discharge water, which will ultimately reach natural waterways, the center said.

Resources

Excerpts courtesy  of http://www.safenano.org/NanoecotoxicologyLymnea.aspx

Excerpts courtesy  of http://www.energy-daily.com/reports/Self-powered_devices_may_soon_be_possible_999.html
Excerpts courtesy  ofhttp://www.dhigroup.com/News/NewsArchive/2006/MappingOfNanoproducts.aspx

Excerpts courtesy  of http://www.environmentalhealthnews.org/ehs/newscience/silver-is-potent-neurotoxicant

Image courtesy of courtesy  http://sci.csc.mrc.ac.uk/images/gallery-nanoparticle-toxicity-large.jpg

Primitive cells developed at Harvard

“Jack Szostak, a molecular biologist at Harvard Medical School, is building simple cell models that can almost be called” life”. Szostak’s protocells (primitive cells) are built from fatty molecules that can trap bits of nucleic acids that contain the source code for replication. Combined with a process that harnesses external energy from the sun or chemical reactions, they could form a self-replicating, evolving system that satisfies the conditions of life, but isn’t anything like life on earth now, but might represent life as it began or could exist elsewhere in the universe.”

Click on link to see video of the cells.

http://blog.wired.com/wiredscience/2008/09/biologists-on-t.html?npu=1&mbid=yhp