“Last antibiotic standing-losing to Gonorrhea”

The last line of defense for treating gonorrhea is crumbling, according to an article published in the July 8 issue of the Centers for Disease Control and Prevention’s (CDC’s) Morbidity and Mortality Weekly Report.

Cephalosporins, the last class of antibiotics that treat gonorrhea, seem to be losing their effectiveness as the pathogen quickly evolves to bypass the antibiotic.

After 10 years of study, the CDC researchers studying gonorrhea cultures show that higher doses of antibiotics are needed to inhibit growth in the lab The gonorrhea samples collected through the CDC’s Gonococcal Isolate Surveillance Project from male patients in 30 US cities. Close to 6000 isolates were collected each year.

A pattern of emerging resistance is developing says Gail Bolan, MD, director of CDC’s Division of Sexually Transmitted Disease Prevention.

Although no treatment failures have been reported yet in the United States, there have been reports from Asia and other parts of the world suggesting gonorrhea’s declining susceptibility to cephalosporin, said Hillard Weinstock, MD, MPH, from the same division.

At an Impasse

Historically, since the 1930s and 1940s, antibiotics have treated gonorrhea. However, during the past 40 years, the bacteria Neisseria gonorrhoeae has developed resistance to several drugs, including sulfonamides, penicillin, and tetracycline. As recently as 2007, the CDC stopped recommending any fluoroquinolone regimens to treat gonorrhea, leaving cephalosporins the last class of antibiotics standing.

The CDC is down to recommending a cephalosporin (cefixime or ceftriaxone), along with a macrolide antibiotic, preferably azithromycin. Ceftriaxone is the most effective cephalosporin for treating gonorrhea, and azithromycin is better than doxycycline for dual therapy with ceftriaxone, the CDC notes. (Dosing recommendations are available in the article.)

Gonorrhea is one of the most common sexually transmitted diseases. Among serious health consequences, it can lead to infertility in women and increase a person’s risk of acquiring HIV.

Given the possibility of rising resistance, clinicians should be on the lookout for treatment failures, Dr. Bolan said, which will show up as persistent symptoms or a positive follow-up test despite treatment with CDC-recommended antibiotics. Clinicians should also obtain specimens for gonococcal culture from patients whose treatments may have failed. “You need to find labs that are still doing the [gonococcal] culture,” she said.

CDC Recommendations

The CDC recommends that individual providers:

  • promptly treat all patients diagnosed with gonorrhea according to CDC Treatment Guidelines,
  • obtain cultures to test for decreased susceptibility from any patients with suspected or documented gonorrhea treatment failures, and
  • report any suspected treatment failure to local or state public health officials within 24 hours, helping to ensure that any future resistance is recognized early.

Clinicians who care for patients with gonorrhea, especially men who have sex with men in the western United States, should consider having patients return 1 week after treatment for test-of-cure with culture, preferably, or with nucleic acid amplification tests. The CDC report notes that the pattern of cephalosporin susceptibility in the West and among men who have sex with men during 2009 to 2010 resembles the drop in effectiveness observed earlier when a fluoroquinolone-resistant N gonorrhoeae emerged in the United States.

Although Dr. Bolan said she was not aware of any new drug development in the pipeline, the CDC and the National Institutes of Health are running a treatment trial on existing drugs: gentamicin, azithromycin, and gemifloxacin. The trial is expected to yield results by late 2012, said Bob Kirkcaldy, MD, MPH, from the CDC’s Office of Workforce Development and Division of STD Prevention.

“We really do want to have more treatment trials so that we have more treatment options down the pike,” Dr. Bolan said.

However, the development of new antibiotics is unlikely, according to Brad Spellberg, MD, author of Rising Plague: The Global Threat from Deadly Bacteria and Our Dwindling Arsenal to Fight Them. A fellow of the Infectious Diseases Society of America who sits on its antimicrobial availability taskforce, Dr. Spellberg characterized the next several decades as “a very barren period of time” in terms of antibiotics development.

Dr. Spellberg offered 3 reasons to explain his outlook: First, there is a significant scientific challenge. After 60 years of antibiotic discovery, all the low-hanging fruit has been plucked, and developing new antibiotics would be difficult. Second, pharmaceutical companies have found that they make much more money off drugs that target chronic illnesses, not ones consumers will take for only 14 days. Third, “nobody even knows how to do drug trials for antibiotics anymore,” Dr. Spellberg said, and the US Food and Drug Administration’s requirements, he explained, are unclear, infeasible, and/or unreasonable.

“There’s never going to be an endgame to this,” he said. Industry, he predicted, will exit antibiotic development. “It doesn’t make enough money for them, and the regulatory morass exacerbates the problem.” Morb Mortal Wkly Rep. 2011:60;873-877. Full text

What are the signs and symptoms of gonorrhea?

Some men with gonorrhea may have no symptoms at all. However, some men have signs or symptoms that appear one to fourteen days after infection. Symptoms and signs include a burning sensation when urinating, or a white, yellow, or green discharge from the penis. Sometimes men with gonorrhea get painful or swollen testicles.

In women, the symptoms of gonorrhea are often mild, but most women who are infected have no symptoms. Even when a woman has symptoms, they can be so non-specific as to be mistaken for a bladder or vaginal infection. The initial symptoms and signs in women include a painful or burning sensation when urinating, increased vaginal discharge, or vaginal bleeding between periods. Women with gonorrhea are at risk of developing serious complications from the infection, regardless of the presence or severity of symptoms.

Symptoms of rectal infection in both men and women may include discharge, anal itching, soreness, bleeding, or painful bowel movements. Rectal infection also may cause no symptoms. Infections in the throat may cause a sore throat, but usually causes no symptoms.

What are the complications of gonorrhea?

Untreated gonorrhea can cause serious and permanent health problems in both women and men.

In women, gonorrhea is a common cause of pelvic inflammatory disease (PID). About 750,000 women each year in the United States develop PID. The symptoms may be quite mild or can be very severe and can include abdominal pain and fever. PID can lead to internal abscesses (pus-filled “pockets” that are hard to cure) and long-lasting, chronic pelvic pain. PID can damage the fallopian tubes enough to cause infertility or increase the risk of ectopic pregnancy. Ectopic pregnancy is a life-threatening condition in which a fertilized egg grows outside the uterus, usually in a fallopian tube.

In men, gonorrhea can cause epididymitis, a painful condition of the ducts attached to the testicles that may lead to infertility if left untreated.

Gonorrhea can spread to the blood or joints. This condition can be life threatening. In addition, people with gonorrhea can more easily contract HIV, the virus that causes AIDS. HIV-infected people with gonorrhea can transmit HIV more easily to someone else than if they did not have gonorrhea.

How does gonorrhea affect a pregnant woman and her baby?

If a pregnant woman has gonorrhea, she may give the infection to her baby as the baby passes through the birth canal during delivery. This can cause blindness, joint infection, or a life-threatening blood infection in the baby. Treatment of gonorrhea as soon as it is detected in pregnant women will reduce the risk of these complications. Pregnant women should consult a health care provider for appropriate examination, testing, and treatment, as necessary.

Alternative Health Care

Natural medicine’s approach to treating all diseases is to look at the whole person and provide treatment that is specific to that person. Through individualized care in classical homeopathy, nutrition, herbal,oriental and Ayurvedic medicines and stress management care, possibly coupled with tradition drugs a person has the best opportunity to heal, because the body is not simply overwhelmed with a chemical antibiotic in hopes of repeatedly and blindly trying to drive the invader out of the body. Overwhelming the delicate systems of the body with chemicals only surpresses the symptoms of the disease and creates deeper pathology. (For more information-Mary Wolken-editor CMA)

Resources

Excerpts courtesy of  http://goo.gl/D6iqt

‘Vitamin D and diabetes” http://wp.me/p13RKZ-qY

Researchers working at Tufts Medical Center in Boston, under the direction of Professor Anastassios Pittas  reported that 2,000 IU/day of vitamin D, given for 12 weeks, significantly improved pancreatic function in mildly overweight adults with pre-diabetes. Unfortunately, the lead author, Dr. Joanna Mitri, did not comment on the low dose of vitamin D they used, 2,000 IU/day, which only increased vitamin D levels from 24 to 30 ng/ml. Nor, in spite of it being a randomized controlled trial, did the authors make any new clinical recommendations for the people who paid for their study, the citizens of the United States.

They found that pancreatic function increased by 300 in the vitamin D group, but fell by 126 in the placebo group.

Joanna Mitri, Bess Dawson-Hughes, Frank B Hu, and Anastassios G Pittas.  Effects of vitamin D and calcium supplementation on pancreatic b cell function, insulin sensitivity, and glycemia in adults at high risk of diabetes: the Calcium and Vitamin D for Diabetes Mellitus (CaDDM) randomized controlled trial. AJCN. First published ahead of print June 29, 2011 as doi: 10.3945/ajcn.111.011684.

In the end, they studied 22 volunteers in the vitamin D group and 22 in the placebo group. However, to give you an idea of what a feat this study was, how difficult it was to get enough subjects, they started with 911 subjects yet ended up randomizing only 44 into the vitamin D study. They did a parallel calcium study with 45 subjects, which found calcium had no benefit on pancreatic function.

The same senior author, Professor Anastassios Pittas, recently announced the results of a much larger epidemiological study that showed for every 5 ng/mL increase in vitamin D levels, the risk of developing diabetes dropped by 8%.  However, he was quick to warn that such epidemiological studies should not change clinical recommendations, only randomized controlled trials can do that. Then, when he oversees just such a randomized trial, not a word of clinical advice, only the ever-present request for more research money from the citizens of this country.

http://diabetes.webmd.com/news/20110628/study-vitamin-d-may-cut-risk-of-diabetes

Of course the Food and Nutrition Board will say they never said levels greater than 20 ng/ml had no added benefits, only that no good evidence existed for such a benefit at the time they issued their report. Actually, if you exclude the science of epidemiology, that is still a false statement. The point is that history will record that someone was wrong.  Maybe it will be me and the Vitamin D Council’s recommendation, going into its fifth year, that adults should take at least 5,000 IU per day.  Or maybe it will be Professor A. Catharine Ross, of Penn­sylvania State University, the chairwoman of the recent FNB that concluded 600 IU/day is the Recommended Daily Allowance, all adults need.  Looking at the study published today, it is clear that 600 IU/day would not have resulted in a significant improvement in pancreatic function.

I predict that after most of the randomized controlled trials are out – in another ten years – the FNB will meet again and say “whoops,” it should have been 5,000 IU/day all along. However, by then the premature death count will be in the millions.

For a list of foods highest in vitamin D click here.

Reprinted with permission
John Cannell, MD
Vitamin D Council
1241 Johnson Road, #134
San Luis Obispo, CA 93401
Image courtesy of  abcnews

“Brain tumors up in cell phone users under 20”

 

Cell and cordless phone radiation and cell towers have been implicated as a factor in the demise of the bee and some bird populations now Lennart Hardell, Michael Carlson and Kjell Hansson Mild latest research has found another link between use of mobile and cordless phones and malignant brain tumours.

This new study has been published in the International Journal of Oncology. They concluded that there was a significantly increased risk for glioma from the long-term use of a mobile or cordless phone.

The risk worst for early mega users

The 3 potentially deadly sins for excessive cell users:

  • began using a cell/ cordless phone before you were 20 years old
  • using it constantly – too many hours,
  • carrying it on your body
  • listening with the phone directly on your ear

With first use before the age of 20 – in this group there was almost 5 times the risk after 10 years cordless/cell phone use.

Pooled analysis was performed of two case-control studies on patients with malignant brain tumours diagnosed during 1997-2003 and matched controls alive at the time of study and one case-control study on deceased patients and controls diagnosed during the same time period. Cases and controls or relatives to deceased subjects were interviewed using a structured questionnaire. Replies were obtained for 1,251 (85%) cases and 2,438 (84%) controls.

Highest overall risk was found for the most common type of glioma, astrocytoma. People who had used a wireless phone for more than ten years and begun its use before the age of 20 had increased risks of 95%.

Began your excessive use of the cordless/ cell phone after age 20?

If you began an excessive unprotected use of the mobile phone and your older the increased risk was between 1.3-fold and 1.5-fold if they had used any type of wireless phone for more than ten years.

Please teach our children that mobile/cell phone  use holds a danger to their long-term health and well-being and to use their mobile phones for essential calls only.

Text or use air-tube hands free headsets with a devise attached to protect them from some of the radiation from the phone.  Remember even in off  mode the Electromagnetic Radiation (EMFs.) is reduced, but not eliminated.  All devises with wiring have energy fields that give off EMFs.

Encourage the telecom industry to find ways to protect our health not bury us early from the radiation from mobile devises and cell phone towers.


Excerpts courtesy of   http://bit.ly/jhIZop

Image courtesy of   http://bit.ly/jcDG0r

“Organic ketchup rules”

Their is an art and science to creating a great tasting full bodied organic ketchup. Burgers and hot dogs, brats and grilled chicken and steaks for some need ketchup.


The Stir
launched How to Cook a Wiener & Eat It blind taste test of 10 ketchup brands to determine which ones had superior tomato flavor and consistency, and which ones were disappointingly watery and bland.

For the ketchup taste test each person was blindfolded then sampled the following 10 brands (using McDonald’s French Fries for dipping) and chose the two best and two worst based on flavor and consistency:

  1. Whole Foods 365 Organic Tomato Ketchup
  2. Whole Foods 365 Ketchup
  3. Generic Tomato Ketchup (Best Yet)
  4. Heinz Tomato Ketchup
  5. Heinz Organic Tomato Ketchup
  6. No Salt Added Heinz
  7. Reduced Sugar Heinz
  8. Sir Kensington Gourmet Scooping Ketchup
  9. Hunt’s Tomato Ketchup
  10. Hunt’s Tomato Ketchup (no salt)

Ketchup is one of the easiest of all naturally fermented foods to make and keep in your own kitchen. I made my first batch ever a few weeks ago, and it truly takes common ketchup as previously known to a whole new level.

The other option is to make your own like the one from Sally Fallon’s book Nourishing Traditions recipe on page 104:

Lynn’s Organic Ketchup Recipe

3 cups canned, organic tomato paste
¼ cup whey (liquid from plain yogurt)
1 Tbls sea salt
½ cup maple syrup
¼ tsp cayenne pepper
3 cloves peeled & mashed garlic
½ cup fish sauce fish sauce (find in most any market)
Just mix together in a wide-mouth glass jar, leave at least an inch below the top and leave it at room temperature for 2-3 days before putting into the refrigerator.

Recipe makes a whole quart.

Excerpts courtesy of   http://yhoo.it/jpVA8i

Excerpts courtesy of   http://bit.ly/lc2YRf

Image courtesy of  http://bit.ly/jgTGFy

“15 most contaminated fruits and veggies”

If you make a copy of Environmental Working Group (EWG’S) 2011 Shopper’s Guide. It will helps cut consumer pesticide exposure and consumption.

EWG just released their seventh edition of its Shopper’s Guide to Pesticides in Produce with updated information on 53 fruits and vegetables and their total pesticide loads.
Analysts at EWG synthesized data collected from the U.S. Department of Agriculture and the Food and Drug Administration from 2000 to 2009. Produce is ranked based on a composite score, equally weighing six factors that reflect how many pesticides was found in testing of on each type of the produce and at what levels. Most samples are washed and peeled prior to being tested, so the rankings reflect the amounts of the chemicals likely present on the food when is it eaten.
Apples now the number one most pesticide laden fruit or vegetable when tested by USDA, showed up on 98 percent of the more than 700 apple samples tested.
Buy fruits and vegetables carefully if you are not able to buy clean pesticide freee local produce/organic.
The high toxicity of pesticides both to  human health and the environment should make more families and individuals wary of eating or using them. Pesticides poisoning has been linked to nervous system disorders, cancer, hormone system disruption learning challenges in children.
Even small amounts of these chemicals add up and can impair a child’s health when they’re exposed during the early, critical stages of their development. When pesticide sprayers have to bundle up in astronaut-like suits for protection, it’s clear parents want to feed their families food containing as little of these toxic chemicals as possible.”
Avoid exposure to pesticides, including pesticide residues on food.”
EWG’s Shoppers Guide is available for fee as a PDF download at http://www.ewg.org/foodnews/. An iPhone app will be available in the near future. For a small donation, consumers can also have a version of the guide sent to them as a bag tag that can be attached to reusable shopping bags.

1. apples  2  celery   3  Strawberries

4  Peaches  5  Spinach  6  Nectarines – imported

7  Grapes – imported  8  Sweet bell peppers  9  Potatoes

10  Blueberries ( domestic )  11  Lettuce  12  Kale/collard greens
13  Cilantro   14  Cucumbers   15  Grapes – domestic

EWG is a nonprofit research organization based in Washington, DC that uses the power of information to protect human health and the environment.

Excerpts courtesy of  EWG

Image courtesy of  http://bit.ly/kXfnYA

“House of Rep. votes no on GM salmon”

GMO salmon goes down in flames in US House of Representatives.
Good news!

The American consumer has been heard. Now will the Senate follow suite?

The The FDA has lead no studies to uncover the long-term health effects from genetically modified salmon or any other GM foods. The FDA has long held that consumers should not even know which foods contain genetically modified ingredients.

Many consumers in the US mistakenly believe that the FDA approves GM foods through rigorous, in-depth, long-term studies. In reality, the agency has absolutely no safety testing requirements. Instead the agency relies on research from companies like Monsanto that produce the GMO products for their scientific evidence of safety. Sort of like relying on a bully to gently take care of a class of wild toddlers.

GMOs,products are produced by modifying the organism’s genetic code with some type of poison, chemical or hormone. When this is done to a plant it causes widespread infertility.

Why did the “need ” for more salmon arise?

Seems by damming our rivers and  feeder streams, polluting the head waters with mining wastes and oceans with trash then over fishing these poor creatures their numbers are falling.
So why not grow a frankenfish in a polluted pond or at the ocean’s edge in pens and feed them chicken feed or better yet frankinfood and inject them with chemicals to encourage their growth year around.  YUMMY–YUCK!
Look at this bloated fish-three times the size of the average salmon that tastes like a “salmon” make three times the profit and to heck with the health of people and our oceans.
Why?

  • the pens never can be kept few of wastes.
  • If these fish get loose 5% are fertile and can destroy health fish not just of salmon, but any fish or  other animal or plant population that feeds on it.
  • GM crops and animals are generally banned in the more progressive health conscious nations.
  • Decreased Nutritional Value
  • Antibiotic Resistant Bacteria—Genetic engineers use antibiotic-resistance genes to mark genetically engineered cells. This means that genetically engineered crops contain genes which confer resistance to antibiotics. These genes may be picked up by bacteria which may cause an infection in humans or animals. (New Scientist 1999) 
Gene Pollution Cannot Be Cleaned Up—Once genetically engineered organisms, bacteria and viruses are released into the environment it is impossible to contain or recall them. Negative effects maybe irreversible.
  • Tell your Senate representatives we do not want any frankenfish salmon for on our plates -thank you!

Resources

Excerpts courtesy of   http://bit.ly/mcEEtH

Excerpts courtesy of  http://bit.ly/je1Jpt

Excerpts courtesy of   http://bit.ly/je1Jpt
Image courtesy of http://bit.ly/jTvrPR

“Loosening the bond of coke addiction”

A new cocaine vaccine is being tested in clinical trials. It block dopamine-transport receptors and the “high” it causes. “high.”
The vaccine consists of molecules of cocaine covalently bonded to a large carrier protein, a recombinant cholera toxin B subunit. The cholera subunit is harmless without the other part of the normal virulent cholera A subunit.
This carrier was chosen because that a cholera subunit vaccine has been administered to millions of people without any adverse effects,

Since Americans are rarely exposed to or even vaccinated against cholera, their immune defense system will probably launch a strong defense against this foreignthis protein and the attached cocaine molecule.

The carrier choice was dictated by the knowledge that a cholera vaccine made from this subunit has been administered to millions of people without any adverse effects, and by the fact that Americans are rarely exposed to or vaccinated against cholera, so most would likely mount a new and robust immune response to this protein and the attached cocaine molecule.

After intramuscular injection, the vaccine enters the bloodstream and triggers plasma cells to produce antibodies to the cocaine molecule as a component of the immunogenic cholera protein. This creates an army of antibodies that can latch onto free cocaine molecules in the bloodstream and, because they are too bulky to fit through tight junctions in blood vessels, prevent the drug from leaving the circulatory system and entering tissues and organs.

Since tiny cocaine molecules that are now bound to big antibodies can no longer cross the blood-brain barrier into the brain, where they would ordinarily block dopamine-transport receptors and cause the buildup of dopamine that users perceive as a “high.” Cocaine that is kept from reaching its “target” in the brain is prevented from triggering reward sensations. With continued, regular booster vaccinations, necessary because the antibody titer declines steeply about 3 months after reaching peak levels, the bonds of addiction may be loosened, giving addicts a stab at kicking their habit altogether.

Resources
Excerpts courtesy of  http://bit.ly/iP62jc

Image courtesy of  http://bit.ly/lQAu3w

“A friend=new world”

Each friend represents a world in us, a world possibly not born until they arrive,

and it is only by this meeting that a new world is born.  – Anais Nin

Be a friend today.

 

Improving your health one helpful deed at a time.

Good friends improve heart energy, endorphins the feel good hormones that decrease the adverse effects of chronic stress and over emotionalism.

Friends are good for your well-being.

 

 

Resources

Quote courtesy of http://bit.ly/jKCGY4

Image courtesy of http://bit.ly/mdCOwA

“Step up to the new Food Plate?”

The old question What’s on your plate has taken on new meaning today with the unveiling of the new Food Plate image that will replace the food pyramid. Government (USDA) hopes that Americans who found  following the dietary guidelines of the food pyramid challenging will step up to the plate and eat healthier now.

It’s an icon that works, says WebMD nutrition director Kathleen Zelman, RD.
“We now have an easy-to-understand layout of what constitutes a healthy meal,” Zelman says. “Whether you are grocery shopping, packing lunches, or assembling a meal on a plate, the new food plate icon will serve as a constant reminder of the essential ingredients for a nutritious meal — five easy pieces.”
The icon makes it clear that fruits and veggies should make up half of your meal, while protein is the smallest part of the plate. The grain portion is a bit larger and still offers the advice to “make half your grains whole,” which some nutritionists say leaves too much room for less healthy refined grains such as white rice and white bread.
Other top-line advice accompanying the icon is less controversial:
Balance calories by enjoying food but eating less, and by avoiding oversize portions.
Eat more good stuff: Make half the plate fruit and vegetables, switch to nonfat or low-fat milk.
Eat less bad stuff: Look for lower-sodium soups, breads, and frozen meals; drink water instead of sugary drinks.
In the fall, the USDA will launch a suite of interactive web-based tools including:
Daily, personalized food plans.
Daily food plans for kids and preschoolers.
Daily food plans for new mothers and pregnant women.
MyFoodapedia: information on food groups, calories, and food comparisons.
Food Tracker: feedback on your food intake and physical activity
Food Planner: a tool to plan meals that will help you reach personal goals.

Resources

Excerpts courtesy of  http://bit.ly/k7Ghwrsrc=nldne

Excerpts courtesy of  http://bit.ly/j1GZkj

Image courtesy of  http://bit.ly/l8sLlX

“Pesticides and Parkinson’s disease”

Researchers at UCLA announced they had discovered a linked Parkinson’s disease to two chemicals commonly sprayed on crops to fight pests.
For farmers who constantly work with pesticides and for people living near where farm fields the risk for Parkinson’s disease increased by 75 percent. The three culprits are fungicide maneb, the herbicide paraquat and pesticide, ziram.

Further study indicated that individuals working in building near the fields like in school teachers, fire fighters, office workers or clerks risk from secondary (ambient) exposure is 80 per cent.
There is strong evidence in humans that the combination of the three chemicals confers a greater risk of Parkinson’s than exposure to the individual chemicals alone. Because these pesticides affect different mechanisms leading to cell death, they may act together to increase the risk of developing the disorder: Those exposed to all three experienced the greatest increase in risk.

Scientists knew that in animal models and cell cultures, such pesticides trigger a neurodegenerative process that leads to Parkinson’s, a degenerative disorder of the central nervous system that often impairs motor skills, speech and other functions and for which there is no cure.
The disease has been reported to occur at high rates among farmers and in rural populations, contributing to the hypothesis that agricultural pesticides may be partially responsible.

Exposure to these toxic chemicals may have occurred years before the onset of motor symptoms, when a diagnosis of Parkinson’s is made.

Avoid pesticide use.

Ziram synuclein accumulated in dopamine neurons, selectively killing them. When it was given systemically to rodents, it reproduced many of the features of Parkinson’s disease.
Excerpts courtesy of  http://bit.ly/jdN63I